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Artemis Operations Center was the Artemis Global Security's headquarters in the Caribbean Sea.

Operation: OFF Certification[]

In Artemis Operations Center's airspace, Captain David Crenshaw and Major Talbot fly an F-15 ACTIVE to conduct the OFF enhanced flight system training exercise until Crenshaw received the OFF certification.

Operation: Stiletto[]

Crenshaw was sent alone to the Caribbean Sea to disable the Artemis' advanced early warning radar system in order to clear the way for Gargoyle Flight, a United States Air Force bomber squadron, to destroy the Artemis Operations Center. Although the attack succeeded, the base was completely empty as Artemis had launched all its forces to invade the United States of America.